PROBLEM TO BE SOLVED: To provide a production method of a functional cross-linked structure bonded with a physiological active substrate.SOLUTION: A production method of a functional cross-linked structure comprises reacting a natural polymer having at least one group selected from OH and amino groups and a COOH group in repeating units with a physiological active substance having an OH group or an amino group, in water in the presence of a water-soluble dehydration condensation agent, to bond the physiological active substance to the natural polymer through an ester bond or an amide bond with the COOH group and simultaneously conducting a cross-linking reaction of the natural polymer.COPYRIGHT: (C)2016,JPO&INPIT【課題】生理活性物質を結合した機能性架橋構造体の製造方法を提供する。【解決手段】OH基及びアミノ基からなる群から選ばれる少なくとも1種とCOOH基を繰り返し単位に有する天然高分子を水中で水溶性脱水縮合剤の存在下にOH基又はアミノ基を有する生理活性物質と反応させて、天然高分子のCOOH基とエステル結合又はアミド結合を介して生理活性物質を結合し、かつ、前記天然高分子の架橋反応を行うことを特徴とする、機能性架橋構造体の製造方法。【選択図】図2
