SURJIT BHIMARAO DIXIT,THOMAS SPRETER VON KREUDENSTEIN,GORDON YIU KON NG,NINA E. WEISSER
申请号：
HK15108247.7
公开号：
HK1207575A
申请日:
2015.08.25
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3.
