Sanaria Inc.;Antigen Discovery, Inc.;The United States of America,as represented by the Secretary, Department of Health and Human Service
发明人:
Philip FELGNER,Stephen L. HOFFMAN,Robert SEDER
申请号：
US14914869
公开号：
US20160216276A1
申请日:
2014.09.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are diagnostic assays for identifying individuals that are protected against Plasmodium falciparum caused malaria. Such assays are particularly useful for determining not only the protective efficacy of Pf whole parasite vaccines for individual subjects, but also within populations of vaccinated subjects. The assays comprise the use of proteomes representing at least 50% of Pf, preferably coupled to a solid phase as a fixed array. The arrays are used to probe the sera of human subjects, particularly subjects of human clinical trials of whole parasite malaria vaccines as well as public health vaccination campaigns. Serum samples with antibody profiles most strongly reactive in multiplex to CSP and MSP5 demonstrate a sensitivity of from 92% to 100% and a specificity of from 84% to 89%.
