PROBLEM TO BE SOLVED: To provide a distribution ratio regulator of intestinal bacterial flora which can regulate the distribution ratio of intestinal bacterial flora in a shorter period at a low dose.SOLUTION: A distribution ratio regulator of intestinal bacterial flora comprises γ-oryzanol and biocompatible particles which include the γ-oryzanol. Preferably, the biocompatible particles comprise polylactide glycolide copolymer. The distribution ratio regulator of intestinal bacterial flora may be considered to decrease the ratio of Firmicutes/Bacteroidetes in intestinal bacterial flora.SELECTED DRAWING: Figure 16COPYRIGHT: (C)2018,JPO&INPIT【課題】低用量でより短期間に腸内細菌叢の構成比率を調整できる腸内細菌叢構成比率調整剤を提供する。【解決手段】腸内細菌叢構成比率調整剤は、γ-オリザノールと、前記γ-オリザノールを内包する生体適合性粒子と、を含む。好ましくは、前記生体適合性粒子は、ポリラクチドグリコライド共重合体を含む。また、腸内細菌叢構成比率調整剤は、腸内細菌叢におけるFirmicutes/Bacteroidetesの比を減少させる、こととしてもよい。【選択図】図16
