LIM, FLORENCIA,TROLLSAS, MIKAEL O.,NGO, MICHAEL HUY,HU, JIE,HOSSAINY, SYED F. A.,SHERMAN, DAVID J.
申请号：
ES09791759
公开号：
ES2445097T3
申请日:
2009.08.20
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
An implantable medical device comprising: a device body； a coating arranged on at least a part of the outer surface of the device body, at least one layer of the coating comprising: a polymer selected from a group consisting of a semi-crystalline AB block copolymer, and a semi-crystalline ABA block copolymer: where B is a polyethylene glycol block with a weight average molecular weight of 1000 to 30000 Daltons, and A is formed from monomers comprising glycolide； and one or more monomers selected from the group consisting of L-lactide, D-lactide, meso-lactide, and combinations thereof； where the molar concentration of ethylene glycol in the polymer is between 1% and 20% and the molar concentration the sum of L-lactide, D-lactide, and meso-lactide in block A is between 70% and 95%； and where the average molecular weight by weight of the polymer is not less than 50,000 Daltons and is not greater than 1,000,000 Daltons, and a medicament； wherein the weight ratio of drug to polymer is less than 1； and where any of the average molecular weight of the poly (ethylene glycol) block, the molar concentration of ethylene glycol, and the molar concentration of the sum of L-lactide, D-lactide, and meso-lactide in the Avaria block at most ± 15 %.Un dispositivo médico implantable comprendiendo: un cuerpo de dispositivo； un revestimiento dispuesto sobre al menos una parte de la superficie exterior del cuerpo de dispositivo, almenos una capa del revestimiento comprendiendo: un polímero seleccionado de un grupo que consiste en un copolímero de bloque A-B semicristalino, y uncopolímero de bloque A-B-A semicristalino: donde B es un bloque de polietilenglicol con un peso molecular promedio en peso de 1000 a 30000Daltons, y A está formado a partir de monómeros que comprenden glicólido； y uno o más monómerosseleccionados del grupo que consiste en L-láctido, D-láctido, meso-láctido, y combinaciones de losmismos； donde la concentración molar de etilenglicol en el polímero es de entre 1% y 20
