PROBLEM TO BE SOLVED: To provide a novel graft material that can achieve an effect as good as an autologous bone formulated graft material without the use of an autologous bone, and is adaptable to intractable synostosis deficiency.SOLUTION: Provided is a pseudo-arthrosis therapeutic preparation containing only (1) Ala-BMP-2 and (2) β-TCP madreporite (preferably, β-TCP madreporite containing micro-pores having a pore diameter of approximately 1 μm and macro-pores having a pore diameter of several hundred μm, as well as having a porosity of 60% or more) as an active ingredient. Preferably a pseudo-arthrosis therapeutic preparation is for mammals except humans, and in particular for pet animals, such as dogs and cats.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2016,JPO&INPIT【課題】自家骨を用いることなく、自家骨配合移植材と同等の効果を奏する、難治性の骨癒合不全に適応可能な新規移植材を提供すること。【解決手段】活性成分として、(1)Ala-BMP-2と、(2)β-TCP多孔体(好ましくは、気孔経1μm前後のミクロ気孔と、気孔径数百μmのマクロ気孔とを含み、かつ気孔率が60%以上のβ-TCP多孔体)のみを含む、偽関節治療用製剤、好ましくは、ヒトを除く哺乳動物、特にイヌ、ネコなどのペット動物における偽関節治療用製剤。【選択図】図2
