MAGNUS NILSSON,LOURDES ODEN,PIA KAHNBERG,URSZULA GRABOWSKA
申请号：
BRPI0813763
公开号：
BRPI0813763A2
申请日:
2008.06.26
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
Compounds of the formula II: wherein R2 is the side chain of leucine, isoleucine, cyclohexylglycine, O-methyl threonine, 4-fluoroleucine or 3-methoxyvaline； R3 is H, methyl or F； Rq is trifluoromethyl and Rq&prime； is H or Rq and Rq&prime； define keto； Q is a p-(C1-C6alkylsulphonyl)phenyl- or an optionally substituted 4-(C1-C6alkyl)piperazin-1-yl-thiazol-4-yl- moiety have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
