Jorge Barbe Garcia;Ignacio Badiola Saiz;Montserrat Llagostera Casas;Maria Elena Garrido Ocana;Montserrat Bosch Gallego;Ana Maria Perez De Rozas Ruiz De Gauna
发明人:
Jorge Barbe Garcia,Ignacio Badiola Saiz,Montserrat Llagostera Casas,Maria Elena Garrido Ocana,Montserrat Bosch Gallego,Ana Maria Perez De Rozas Ruiz De Gauna
申请号：
US12865287
公开号：
US08685413B2
申请日:
2009.01.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P. multocida . Said mutants are defective in fur ompH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P. multocida , or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants.
