FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to an aminopropylidene derivative presented by formula wherein R1 and R2, which may be identical or different, represent hydrogen or a substitute specified in the following (a)-(c), provided the case of both representing hydrogen is excluded: (a) carbonyl substituted with hydroxy, alkoxy or hydroxy alkylamino, (b) carbonylalkyl substituted by hydroxy or alkoxy, and (c) acrylic acid including its alkyl ester, R3 and R4, which may be identical or different, represent hydrogen, alkyl which may be substituted by phenyl or cycloalkyl, or R3 and R4, which together form a heterocyclic ring with a nitrogen atom bound thereto, represent pyrrolidino, piperidino, which may be substituted by oxo or piperidino, piperazinyl substituted by alkyl or penyl, morpholino or thiomorpholino； A means oxo or is absento, B represents canbon or oxygen； one of X and Y represents carbon, while the other one represents sulphur, a part represented by a dash line represents a single bond or a double bond, and a wavy line represents a cys-form and/or a transform. Also, the invention refers to a pharmaceutical composition exhibiting histamine receptor antagonist activity on the basis of said compounds.EFFECT: there are produced new compounds and pharmaceutical compositions thereof, which can be used in medicine for treating asthma, allergic rhinitis, pollen allergy, hives and atopic dermatitis.10 cl, 12 tbl, 58 exНастоящее изобретение относится к аминопропилиденовому производному, представленному формулой (I), где R1 и R2, которые могут быть одинаковыми или отличными друг от друга, представляют собой водород или заместитель, выбранный из следующих (а)-(с), при условии, что случай, когда оба представляют собой водород, исключается: (а) карбонил, замещенный гидрокси, алкокси или гидроксиалкиламино, (b) карбонилалкил, замещенный гидрокси или алкокси, и (с) акриловая кислота, включая ее алкиловый эфир, R3 и R4, которые могут быть оди
