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8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
专利权人:
THERAVANCE BIOPHARMA R&D IP; LLC
发明人:
Daniel D. Long,John R. Jacobsen,Lan Jiang
申请号:
US15496269
公开号:
US10081626B2
申请日:
2017.04.25
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I):wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
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