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8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
专利权人:
Daniel D. Long;John R. Jacobsen;Lan Jiang
发明人:
Daniel D. Long,John R. Jacobsen,Lan Jiang
申请号:
US13527942
公开号:
US20130158060A1
申请日:
2012.06.20
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I):wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
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