Mahendra S. Rao,Nasir Malik,Raymond Funahashi,Jizhong Zou
申请号：
US15035958
公开号：
US09951353B2
申请日:
2014.11.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are recombinant polynucleotide-binding polypeptides, recombinant fusion proteins made with the described polynucleotide-binding polypeptides, methods of using the described recombinant polynucleotide-binding polypeptides and recombinant fusion proteins to modify genomic DNA of cells and, in some embodiments, create recombinant cells. Methods are also provided herein for genetically modifying a neuronal stem cell. Methods are also provided for treating a neurological disorder in a subject that include the administration of genetically modified neuronal stem cells produced by the methods disclosed herein.
