UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
Jianhua Luo,Zhanghui Chen,Yanping Yu,George Michalopoulos,Joel B. Nelson,Chien-Cheng Tseng
申请号：
US16427212
公开号：
US20190282708A1
申请日:
2019.05.30
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to methods for treating patients having cancer or a premalignant or neoplastic condition. It is based, at least in part, on the discovery that a genome editing technique that specifically targets a fusion gene can induce cell death in a cancer cell other than a prostate cancer cell, e.g., a hepatocellular cancer cell, having the fusion gene. The present invention provides methods for treating cancer patients that include performing a genome editing technique targeting a fusion gene present within one or more cells of a subject to produce an anti-cancer effect.
