CAMPBELL, JOHN EMMERSON,DUNCAN, KENNETH WILLIAM,FOLEY, MEGAN ALENE,HARVEY, DARREN MARTIN,KUNTZ, KEVIN WAYNE,MILLS, JAMES EDWARD JOHN,MUNCHHOF, MICHAEL JOHN
申请号：
CA3021062
公开号：
CA3021062A1
申请日:
2017.04.17
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.
