TRAN, Chinh Viet,RUEBSAM, Frank,MURPHY, Douglas Eric,DRAGOVICH, Peter,ZHOU, Yuefen,CHEN, Lijian,KUCERA, David,BLATTER, Fritz,VIERTELHAUS, Martin
申请号：
ES08733076
公开号：
ES2578302T3
申请日:
2008.04.02
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula I ** Formula ** in which X is N or CR3, A is ** Formula ** or ** Formula ** Ring B is 6-membered aryl or heterocyclyl, optionally substituted with 1-3 residues R1, where R1 is H, halo, nitro, -CHR4-S (O) 2R5, -C (S (O) 2R5)>； = CHR4-, -NR5R6, -NR4S (O) 2R5 or -NR4S (O ) 2NR5R6, in which R4, R5 and R6 are independently H, C1-C6 alkyl, C3-C8 cycloalkyl, C (O) O- (C1-C6 alkyl), aryl or heterocyclyl, or R4 and R5 or R5 and R6 they combine with the atom (s) to which they are attached to form a 5 or 6 membered hetericyclyl ring, R2 is H, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkylene (C3 cycloalkyl) C8), -C1-C6 alkylene (aryl), -C1-C6 alkylene (heterocyclyl), aryl or heterocyclyl, R3 is H, halo or C1-C6 alkyl, Z is - (CR13R14) n- or O, n is 1 or 2, R7 and R8 are independently H or C1-C6 alkyl, R9, R10, R11, R12, R13, R14, R15 and R16 are independently H, C1-C6 alkyl, hydroxy or halo, wherein the alkyl moieties, alkylene, aryl, cycloalkyl or hetero Previous cyclyls provided in R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are each optionally and independently substituted with 1 to 3 substituents selected from alkylamine, amino, aryl, cycloalkyl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 alkylamine, C1-C6 dialkylamine, C2-C6 alkenyl or C2-C6 alkynyl, wherein each of them may be interrupted by one or more heteroatoms, carboxyl, cyano, halo, hydroxy, keto, nitro, -C (O) OH, -C (O) NH2, -C (O) (alkylamine C1-C6), -C (O) (C1-C6 dialkylamine), -C (O) 2- (C1-C6 alkyl), -C (O) 2- (C3-C8 cycloalkyl), -C (O) 2- (aryl), -C (O) 2- (heterocyclyl), -C (O) 2- (C1-C6 alkylene) aryl, -C (O) 2- (C1-C6 alkylene) heterocyclyl, -C ( O) 2- (C1-C6 alkylene) cycloalkyl, -C (O) (C1-C6 alkyl), -C (O) (C3-C8 cycloalkyl), -C (O) (aryl), -C (O) (heterocyclyl), -C (O) (C1-C6 alkylene) aryl, -C (O) (C1-C6 alkylene) heterocyclyl and -C (O) (C1-C6 alkylene) cycloalkyl lo, wherein each of the above optional substitu
