Hendrika Maria Gerarda Willems,Per Kallblad,Ian Robert Hardcastle,Roger John Griffin,Bernard Thomas Golding,John Lunec,Martin E. M. Noble,David R. Newell,Alan H. Calvert
申请号：
US11574531
公开号：
US08258175B2
申请日:
2005.08.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A compound of formulaor a prodrug and/or a pharmaceutically acceptable salt thereof, wherein X is O, N or S R1 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl R2 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl R3 is hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl and R4-R7, is used to represent groups R4, R5, R6 and R7 which are H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, halo, CF3, NH2, NO2, COOH, C═O.
