Regeneron Pharmaceuticals, Inc;Yale University;Institute For Research In Biomedicine (IRB)
发明人:
Herndler-Brandstetter Dietmar,Flavell Richard A.,Frleta Davor,Gurer Cagan,Manz Markus Gabriel,Murphy Andrew J.,Palm Noah W.,Shan Liang,Stevens Sean,Strowig Till,Yancopoulos George D.,de Zoete Marcel
申请号：
US201615097239
公开号：
US10123518(B2)
申请日:
2016.04.12
申请国别(地区):
美国
年份:
2018
代理人:
Smeland Tor`Gont Ilona`Rubin Michael B.
摘要：
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.
