PROBLEM TO BE SOLVED: To provide a high concentration antibody-containing formulation that is stable and suitable for subcutaneous administration, and in which creation of dimer or deamidation is suppressed during long-term storage.SOLUTION: An antibody-containing solution formulation contains arginine (50 to 1500 mM, preferably 100 to 300 mM) and methionine (10 to 200 mM, preferably 10 to 50 mM), may contain histidine and/or tryptophan as an additional component, in which antibody concentration is 50 mg/ml or more preferably 100 mg/ml or more, more preferably 120 mg/ml or more, pH is 4 to 8, viscosity is 2 to 15 mPa s, which is produced without including a freeze-drying process, and an antibody is an interleukin-6 receptor antibody.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】長期保存時の二量体生成や脱アミド化が抑制された、安定な、皮下投与に適した高濃度抗体含有製剤の提供。【解決手段】アルギニン（５０～１５００ｍＭ、好ましくは１００～３００ｍＭ）及びメチオニン（１０～２００ｍＭ、好ましくは１０～５０ｍＭ）を含有し、追加の成分として、ヒスチジン及び／又はトリプトファンを含有してもよく、抗体濃度が５０ｍｇ／ｍｌ以上好ましくは１００ｍｇ／ｍｌ以上、より好ましくは１２０ｍｇ／ｍｌ以上、ｐＨが４～８、粘度が２～１５ｍＰａ・ｓであり、凍結乾燥工程を含まず製造され、抗体がインターロイキン－６レセプター抗体である抗体含有溶液製剤。【選択図】なし
