The invention pertains to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) for use in the treatment or prophylaxis of a blood coagulation disorder, said treatment or prophylaxis comprising administering the recombinant polypeptide and a Factor VIII protein (FVIII) extravascular to a subject having a blood coagulation disorder, wherein said recombinant polypeptide is capable of binding to said FVIII, and wherein the molar ratio of the recombinant polypeptide to be administered to the FVIII to be administered is higher than 50.本發明關於一種用於治療或預防凝血疾病之重組多肽，其包含截短型類血友病因子(VWF)，該治療或預防包含向患有凝血疾病之個體施予該重組多肽且血管外施予第八凝血因子蛋白質(FVIII)，其中該重組多肽能夠與該FVIII結合，且其中欲施予之該重組多肽對欲施予之該FVIII的莫耳比高於50。
