POLYPEPTIDES DU FACTEUR DE VON WILLEBRAND TRONQUE POUR UNE ADMINISTRATION EXTRAVASCULAIRE DANS LE TRAITEMENT OU LA PROPHYLAXIE D'UN TROUBLE DE LA COAGULATION DU SANG

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专利权人:

CSL BEHRING LENGNAU AG

发明人:

PESTEL, SABINE,RAQUET, ELMAR,WEIMER, THOMAS

申请号：

CA3043397

公开号：

CA3043397A1

申请日:

2017.11.10

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The invention pertains to a recombinant polypeptide comprising a truncated von Willebrand Factor (VWF) for use in the treatment or prophylaxis of a blood coagulation disorder, said treatment or prophylaxis comprising administering the recombinant polypeptide and a Factor VIII protein (FVIII) extravascular to a subject having a blood coagulation disorder, wherein said recombinant polypeptide is capable of binding to said FVIII, and wherein the molar ratio of the recombinant polypeptide to be administered to the FVIII to be administered is higher than 50.

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