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Ferrofluids stable in neutral media and modified ferrofluids modifies obtained by modification of the surface of the particles of said ferrofluids
专利权人:
Etienne Duguet
发明人:
Etienne Duguet,Stéphane Mornet,Joseph Portier
申请号:
US10558069
公开号:
US09630838B2
申请日:
2004.05.13
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The invention relates to aqueous dispersions, comprising particles based on a magnetic iron oxide with dimensions of ≦20 nm, the surface of which is modified by the grafting of aminated groups R with a covalent bonding to the surface of said particles, wherein the isoelectronic point of particles with such a modified surface is ≧10. The invention further relates to a method for production of said aqueous suspensions and a method for modification of the surface of the particles present in said dispersions, in particular, by the immobilisation of polysaccharides such as dextrans, particularly for the formulation of magnetic compositions which may be administered in vivo and in particular for the formulation of injectable compositions of contrast agents for MRI.
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