EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION
发明人:
PARK, Eun-Mi,박은미
申请号：
KRKR2015/003189
公开号：
WO2016/111417A1
申请日:
2015.03.31
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to a composition, containing noggin as an active ingredient, for promoting microglia activity or preventing and treating ishemic diseases. It was verified in a middle cerebral artery occlusion (MCAO) animal model that, when administered for two weeks from two weeks after MCAO induction, noggin suppresses cerebral atrophy, promotes the expression of proteins associated with the restoration of brain tissue and the angiogenesis, and promotes microglia activity, thereby contributing to the restoration of brain tissue during the recovery from ishemic diseases.La présente invention concerne une composition contenant de la noggine comme principe actif, destinée à stimuler lactivité de la microglie ou à prévenir et traiter des maladies ischémiques. Il a été vérifié dans un modèle animal de locclusion de lartère cérébrale moyenne (MCAO) que lorsque la noggine est administrée pendant deux semaines, en commençant deux semaines après linduction de la MCAO, cette dernière supprime latrophie cérébrale, favorise lexpression de protéines associées à la restauration du tissu cérébral et à langiogenèse et favorise lactivité de la microglie, contribuant ainsi à la restauration du tissu cérébral pendant la période de guérison de la maladie ischémique.본 발명은 노긴(Noggin)을 유효성분으로 함유하는 소교세포 활성 증진용, 또는 허혈성 질환 예방 및 치료용 조성물에 관한 것으로, 노긴이 중뇌동맥협착(middle cerebral artery occlusion, MCAO) 동물 모델에서 MCAO 유도 2주 후부터 2주 동안 투여하였을 때, 뇌 위축을 억제하고, 뇌 조직 복구와 관련된 단백질들의 발현 및 혈관 신생을 촉진하며, 소교세포의 활성을 증가시킴으로써 허혈성 뇌졸중에서 회복되는 동안 뇌 조직의 복구에 기여하는 것을 확인하였다.
