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PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDE
专利权人:
发明人:
TERINEK MIROSLAV,FABER DOMINIK,KOENIG STEFAN
申请号:
IN6118/DELNP/2013
公开号:
IN300749B
申请日:
2012.01.25
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
The invention relates to a process for the preparation of 3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl)-amide by acylating the oxime oxygen of the compound of formula (VIII), in the presence of a solvent and an acylating agent of formula (XI) R1C(X)-CI (XI) wherein X is oxygen or sulfur R1 is chloro if X is oxygen or sulfur or R1 is C1-C6alkoxy, CH3-C(=CH2)-0-, phenoxy or trichloromethoxy if X is oxygen and a) if R1 is chloro and the compound of formula (XI) was added to the compound of formula (VIII) reacting the so obtained product of formula (Xlla) wherein X is oxygen or sulfur with the compound of formula (IX) b) if R1 is chloro and the compound of formula (VIII) was added to the compound of formula (XI) or R1 is C1-C6alkoxy, CH3-C(=CH2)-0-, phenoxy or trichloromethoxy if X is oxygen reacting the so obtained product of formula (XII) wherein X is oxygen or sulfur R1 is chloro if X is oxygen or sulfur or R1 is C1-C6alkoxy, CH3-C(=CH2)-0-, phenoxy or trichloromethoxy if X is oxygen with the compound of formula (IX). WO2012101139A1
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