Methods may include admixing an additive composition with a hydrocarbon fluid, wherein the additive composition contains at least one inhibitor and at least one sub-micron particle. Additional methods may include providing an additive composition containing at least one inhibitor and at least one sub-micron particle; adding the additive composition to a fluid capable of precipitating at least one of at least of asphaltenes, wax, scale, and gas hydrates; and transporting the fluid containing the additive composition.