충남대학교산학협력단;제주대학교 산학협력단;CHEJU NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
发明人:
KIM, YOUNG HO,김영호,KOH, YOUNG SANG,고영상,KIM, JEONG AH,김정아
申请号:
KR1020100090002
公开号:
KR1020120028043A
申请日:
2010.09.14
申请国别(地区):
KR
年份:
2012
代理人:
摘要:
PURPOSE: Triterpenoid extracted from steamed acanthopanax koreanum leaves, a producing method thereof, and a use thereof are provided to offer an excellent production inhibition effect of tumor necrosis factor-alpha, interleukin-12, and interleukin-6 to users. CONSTITUTION: Triterpenoid or its salt extracted from steamed acanthopanax koreanum leaves has a structure marked with chemical formula 1. The triterpenoid is extracted from the following steps: steaming the acanthopanax koreanum, and extracting the steamed acanthopanax koreanum leaves with alcohol; suspending the obtained extract, and separating alkyl acetate fractions; and processing the alkyl acetate fractions with the column chromatography.본 발명은 화학식 1의 구조를 갖는 트리테르페노이드를 유효성분으로 포함하는 의약, 식품 또는 화장료 조성물에 관한 것이다. 본 발명에 따른 화학식 1의 구조를 갖는 트리테르페노이드는 인터루킨-12 (Interleukin-12), 인터루킨-6 (Interleukin-6) 및 TNF(Tumor necrosis factor)-α 생산 저해 효과가 우수하여, 이들로 인해 유발되는 자가 면역 질환과 패혈증 등의 치료에 유용하게 활용될 수 있다.