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CYTOKINE INHIBITORS
专利权人:
发明人:
BANDGAR BABASAHEB PANDURANG,TOTRE JALINDAR VASANT
申请号:
IN2421/MUMNP/2012
公开号:
IN2012MN02421A
申请日:
2012.10.20
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
The present invention provides compounds represented by general formula (I): wherein, R1 R2, R3, L and T are as defined in the specification, in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, and prodrugs thereof. The invention also relates to processes for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them. The compounds and the pharmaceutical compositions of the present invention are useful in the treatment of a condition or disorder mediated by one or more cytokines selected from Tumor Necrosis Factor-alpha (TNF-oc) and interleukins such as IL-1, IL-6, and IL-8. The present invention further provides a method of treatment of inflammatory disorders by administering a therapeutically effective amount of the said compound of formula (I) or its pharmaceutical composition, to a mammal in need thereof.
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