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תכשירים נוזליים עם ריכוז גבוה של נוגדן אנטי α–tnf
专利权人:
ABBVIE BIOTECHNOLOGY LTD.
发明人:
申请号:
IL22621713
公开号:
IL226217A
申请日:
2013.05.07
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.
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