The present invention provides the compound of formula (I), is suitable for treatment to be related to the disease of the M3 receptor activation effect of enhancing, such as respiratory disease:Wherein (i) R1For C1-C6Alkyl or hydrogen； And R2For hydrogen or group-R7,-Z-Y-R7,-Z-NR9R10,-Z-CO-NR9R10,-Z-NR9-C(O)O-R7Or-Z-C (O)-R7； And R3For lone electron pair or C1-C6Alkyl； Or (ii) R1 and R3The nitrogen connected together with it forms heterocycloalkyl ring, and R2For lone electron pair or group-R7,-Z-Y-R7,-Z-NR9R10,-Z-CO-NR9R10,-Z-NR9-C(O)O-R7Or-Z-C (O)-R7； Or (iii) R1 and R2The nitrogen connected together with it forms heterocycloalkyl ring, and the ring is through group-Y-R7,-Z-Y-R7,-Z-NR9R10,-Z-CO-NR9R10,-Z-NR9-C(O)O-R7Or-Z-C (O)-R7Replace； And R3For lone electron pair or C1-C6Alkyl； R4And R5System is independently selected from by aryl, aryl-condensed Heterocyclylalkyl, heteroaryl, C1-C6The group of alkyl, naphthenic base composition； R6For-OH, C1-C6Alkyl, C1-C6Alkoxy, hydroxyl-C1-C6Alkyl, nitrile, group CONR82Or hydrogen atom； AFor oxygen or sulphur atom； XTo stretch alkyl, stretching alkenyl or stretching alkynyl； R7For C1-C6Alkyl, aryl, aryl-condensed naphthenic base, aryl-condensed Heterocyclylalkyl, heteroaryl, aryl (C1-C8Alkyl)-, heteroaryl (C1-C8Alkyl)-, naphthenic base or Heterocyclylalkyl； R8For C1-C6Alkyl or hydrogen atom； ZFor C1-C16Stretch alkyl, C2-C16Stretch alkenyl or C2-C16Stretch alkynyl； YFor a key or oxygen atom； R9And R10It independently is hydrogen atom, C1-C6Alkyl, aryl, aryl-condensed Heterocyclylalkyl, aryl-condensed naphthenic base, heteroaryl, aryl (C1-C6Alkyl)-or heteroaryl (C1-C6Alkyl)-group； Or R9And R10The nitrogen-atoms connected together with it forms the miscellaneous cyclic rings of the 4-8 atom optionally containing another nitrogen or oxygen atom.本發明提供式(I)之化合物，其適用於治
