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Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
Kenneth Leavitt,Brendan Crowley,Ian M. Bell,Andrew Harvey,Thomas Avery,Dharam Paul,Justin Ripper,Belinda Huff,Rajinder Singh,Laurent Schaeffer,Christophe Joseph,Christophe Morice,Bruno Giethlen,Patric
申请号:
US15318207
公开号:
US09994518B2
申请日:
2015.06.11
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Disclosed are compounds of Formula (IVA), or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof: Formula (IVA), wherein “RIa”, “RIb”, “RIc”, “RId”, “RIe”, are defined herein above, which compounds are believed suitable for use in positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR) receptors, for example, those found in the cerebral cortex and the hippocampus. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Alzheimer's disease (AD), schizophrenia, and Parkinson's disease (PD), or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
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