The present invention discloses crystalline polymorphs of the compounds of formula I, pharmaceutical compositions containing them, and their preparation and application. The compound of formula I of the present invention is as shown in formula I, and its crystal form is crystal form 1, crystal form 2, crystal form 3, crystal form 5, crystal form 6 or crystal form 7. The crystal form stability and chemical stability of each crystal form of the compound of formula I of the present invention is good, and the purity reduction of the chemical stability main component is less than 2%. Each of the crystalline forms of the compound of formula I with high purity can be produced by the production method of the present invention, and the formulation method is suitable for large-scale production. [Chemical 1]本発明では式Ｉの化合物の結晶多形、それを含む医薬組成物、及びその製造方法と応用を開示している。本発明の式Ｉの化合物は式Ｉの示す通りであり、その結晶形は結晶形1、結晶形2、結晶形3、結晶形5、結晶形6または結晶形7である。本発明の式Ｉの化合物の各結晶形の結晶形安定性および化学的安定性は良好であり、化学的安定性主成分の純度軽減は2%未満である。本発明の製造方法により高純度の当該式Ｉの化合物の各結晶形を製造でき、且つそれらの製剤方法は大規模製造に適している。【化１】
