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Modulateurs stéroïdiens non hormonaux de NF-KB pour le traitement d'une maladie
专利权人:
Inc.;Validus Biopharma
发明人:
申请号:
EP14173342.8
公开号:
EP2805720A1
申请日:
2009.05.28
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention is directed to a compound for use in reducing the symptoms of muscular dystrophy, wherein said compound has structural Formula I:wherein:said dashed line indicates an optional double bond;each R1 is hydrogen;R2 is selected from the group consisting of hydrogen and methyl;R3 is selected from the group consisting of hydrogen, hydroxyl, and methyl;or R2 and R3 may be taken together to form a double bond;R4 is -(CO)n(C(R5)(R6))m(R7);R5 and R6 are independently selected from the groups consisting of hydrogen and C1-3 alkyl;R7 is selected from the group consisting of -N(R8)(R9) and -OR10;R8, and R9 are each independently selected from the group consisting of hydrogen, lower alkyl, and -(C(R5)2)pR11; or R8 and R9 may be taken together to form a heterocycloalkyl;R10 is selected from the group consisting of hydrogen, acyl, lower alkyl, and-(C(R5)2)pR11;R11 is selected from the group consisting of hydroxyl and amino;n is 0 or 1;m is an integer between 1 and 3;p is an integer between 1 and 3; andq is an integer between 1 and 4.
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