Anindita Bhoumik,Alan D. Agulnick,Kevin Allen D'Amour
申请号：
US16403446
公开号：
US20190255159A1
申请日:
2019.05.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed herein are universal donor stem cells and cells derived therefrom and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming allogeneic immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor cells disclosed herein are pancreatic endoderm cells that do not express one or more MHC-Class I cell-surface proteins and whose expression of at least one NK activating ligand is disrupted or inhibited.
