ГРАНДИ Гвидо (IT),МАРГАРИТ И. РОС Иммакулада (IT),МАЙОНЕ Доменико (IT)
申请号：
RU2015106791
公开号：
RU2015106791A
申请日:
2013.10.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An immunogenic composition comprising: a) a conjugate comprising a capsular saccharide from GBS serotype Ia conjugated to a carrier protein； b) a conjugate comprising a capsular saccharide from GBS serotype Ib conjugated to a carrier protein； c) a conjugate comprising a capsular saccharide from GBS serotype III conjugated to a carrier protein； d) a conjugate comprising a capsular saccharide from GBS serotype II conjugated to a carrier protein； and e) a conjugate comprising a capsular saccharide from GBS serotype V conjugated to a carrier protein. 2. The immunogenic composition of claim 1, wherein the total amount of capsular saccharides of GBS is ≤70 μg. 3. The immunogenic composition according to claim 1 or 2, wherein each GBS capsular saccharide is present in an amount of 1 to 30 μg per unit dose. An immunogenic composition according to claim 3, wherein each GBS capsular saccharide is present in an amount of 5 μg, 10 μg or 20 μg per unit dose. The immunogenic composition according to claim 1, wherein the amounts of GBS capsular saccharides of serotypes Ia, Ib, II, V and III per unit dose are selected from the group consisting of 20 μg, 20 μg, 20 μg, 20 μg and 20 μg； 10 μg, 10 μg, 10 μg, 10 μg and 10 μg； and 5 μg, 5 μg, 5 μg, 5 μg and 5 μg. 6. The immunogenic composition of claim 5, wherein the amounts of GBS capsular saccharides of serotypes Ia, Ib, II, V, and III per unit dose are 5 μg, 5 μg, 5 μg, 5 μg, and 5 μg. The immunogenic composition of claim 1 or 2, wherein each GBS capsular saccharide is present in an amount of 0.1 to 5 μg per unit dose. The immunogenic composition of claim 7, wherein each GBS capsular saccharide is present in an amount of 0.5, 2.5, or 5 μg per unit dose. The immunogenic composition according to claim 1, where the mass ratio of capsular saccharides of GBS serotypes Ia, Ib, II, V and III is 1: 1: 1: 1: 1.10. The immunogenic composition of claim 9, wherein said composition is for administration to1. Иммуногенная композиция, содержащая:
