The present invention, which provides, a kind of contain Pyridylaminoacetic acid compound that general formula (1) indicates or its pharmacologically medical composition of permissible salt as the treatment or prevention with what glaucoma of effective component. In general formula, R1, R2 and R3 each independently represent hydrogen atom etc.； Y indicates dicyclic heteroaromatic group or group-Q1-Q2 that can be substituted by halogen atom etc., and in the formula, Q1 indicates that arlydene etc., Q2 expression can be by substituted aromatic groups such as halogen atom etc.； Z indicates aromatic group etc. that can be substituted by halogen atom etc..本發明提供一種含有通式(1)表示的吡啶基氨基乙酸化合物或其藥理上可容許的鹽作爲有效成分的用於青光眼的治療或預防的醫藥組合物。通式中，R1、R2和R3各自獨立地表示氫原子等；Y表示可被鹵素原子等取代的雙環式雜芳環基團或基團-Q1-Q2，該式中，Q1表示亞芳基等、Q2表示可被鹵素原子等取代的芳香環基團等；Z表示可被鹵素原子等取代的芳香環基團等。
