Graftys;Centre National de la Recherche Scientifique (C.N.R.S.);Université de Nantes
发明人:
申请号：
EP10706257.2
公开号：
EP2403544B1
申请日:
2010.03.03
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒCa (10.5-1.5x) Ga x (PO 4 ) 7 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein 0 <； x <； 1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca + Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5 % by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.
