Solid self-emulsifying formulation of tamoxifen in combination of antioxidant for enhanced oral bioavailability and antitumor efficacy

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专利权人:

NAT INST OF PHARMACEUTICAL EDUCATION AND RES NIPER

发明人:

Sanyog Jain,Sanyog Jain,AMIT KUMAR JAIN,AMIT KUMAR JAIN

申请号：

IN10/DEL/2014

公开号：

IN2014DE00010A

申请日:

2014.01.03

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The present invention provides a novel solid self-emulsifying formulation comprising tamoxifen in combination with antioxidant such as quercetin, a solid carrier, an oily phase, a surfactant and a co-surfactant. The developed formulation showed enhanced oral bioavailability, improved breast tumor efficacy and reduced the hepatotoxicity.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/