603837 Disclosed herein is a nicotinamide derivative represented by the formula (I) or a salt thereof, wherein the variables are defined in the specification, and a pharmaceutical composition comprising said derivative for use in the treat ment of a Syk-related disease, such as rheumatism and idiopathic thrombocytopenic purpura. Embodiments of the derivative include the following: 6-(cis-2-aminocyclohexylamino)-5-fluoro-2-((8(methylsulphonamide)quinolin-3-yl)amino)nicotinamide, (R)-6-((1-aminobutan-2-yl)amino)-5-fluoro-2-((quinolin-6-yl)amino)nicotinamide, 6-((1R,2S)-2-aminocyclohexylamino)-5-fluoro-2-((isoquinolin-4-yl)amino)nicotinamide, and 5-((6-(cis-2-aminocyclohexylamino)-3-carbamoy1-5-fluoropyridin-2-yl)amino)-N-benzyl-1H-indole-2-carboxamide.
