BALDWIN, IAN ROBERT,BARKER, MICHAEL DAVID,DEAN, ANTHONY WILLIAM,ELDRED, COLIN DAVID,EVANS, BRIAN,GOUGH, SHARON LISA,GUNTRIP, STEPHEN BARRY,HAMBLIN, JULIE NICOLE,HOLMAN, STUART,JONES, PAUL,LINDVALL, MI
申请号：
ES08152215
公开号：
ES2374850T3
申请日:
2004.05.19
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A pharmaceutical composition for inhaled administration comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 is C 1-6 alkyl； C3-7 cycloalkyl or C3-7 cycloalkyl (C1-4 alkyl) -, wherein the C3-7 cycloalkyl is optionally substituted with one or more substituents selected from = O and OH； C4-7 cycloalkyl condensed with an aryl ring； aryl or aryl (C1-6 alkyl) -, wherein the aryl is optionally substituted with one or more substituents selected from C1-6 alkyl, C1-6-CONR6- alkyl, C1-6-CO- alkyl, halogen, - CF3, - (CH2) mOH, -OCF3, C 1-6 alkoxy, C 1-6 alkoxy (C 1-4 alkyl) -, C 1-6 alkoxy-C 2-6 alkoxy, C 1-6 alkoxycarbonyl, -CN, R4R5NCO, R7R8N-, R9R10NCONR11-, HO (CH2) 2-6O-, R12R13NSO2 (CH2) m-, (4-morpholinyl) -C2-6 alkoxy, -NR14SO2-C1-6 alkyl, aryloxy, heteroaryl (optionally substituted with C1-6 alkyl), CO2H, R21R2215 N- (C1-4 alkyl) -, C1-6 alkoxy-CONR23 (CH2) m-, aryl (optionally substituted with C1-6 alkyl)； fused aryl with a C4-7 cycloalkyl ring, in which the cycloalkyl ring is optionally substituted with one or more = O； aryl fused with a heterocyclyl ring, wherein the heterocyclyl ring is optionally substituted with one or more substituents selected from = O, -COC-C1-4 alkyl and C1-4 alkyl； heteroaryl or heteroaryl- (C1-6 alkyl) -, wherein the heteroaryl is optionally substituted with one or more substituents selected from: C1-6 alkyl, aryl- (C1-4 alkyl), C1-6 alkoxy, halogen, alkoxy C1-6-CO； or heterocyclyl optionally fused to an aryl or heteroaryl ring； R2 is hydrogen or C1-6 alkyl； R34 is hydrogen or a group of the formula: wherein R3 is C1-6 alkyl optionally substituted with one or more substituents selected from -OH, -NR16COR15, - NR17R18, -CO2R24, C1-6-CONR25- alkoxy, -CONR26R27, C1-6 alkoxy, C1-6 alkyl-SO2NR33-, or a group having one of the following formulas； C3-7 cycloalkyl； Z aryl or aryl- (C1-6 alkyl) -, wherein the aryl is optionally substituted with one or more substituents selected from C1-6- alkyl, halogen-,
