BALDERES, Paul J.,EASTMAN, Scott W.,ERICKSON, Hans K.,LUDWIG, Dale L.,MOXHAM, Christopher M.,PLOWMAN, Gregory D.,RIGBY, Alan C.
申请号：
PH12016501185
公开号：
PH12016501185A1
申请日:
2016.06.17
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The conjugate of the present invention has significant advantages over other conjugates known in the art by providing a targeted tumor therapy as well as bystander activity to neighboring cells in an important oncology receptor that is only moderately expressed.
