BALDERES, PAUL J.,EASTMAN, SCOTT W.,ERICKSON, HANS K.,LUDWIG, DALE L.,MOXHAM, CHRISTOPHER M.,PLOWMAN, GREGORY D.,RIGBY, ALAN C.
申请号：
SG11201604119Y
公开号：
SG11201604119YA
申请日:
2014.12.11
申请国别(地区):
SG
年份:
2016
代理人:
摘要：
The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The conjugate of the present invention has significant advantages over other conjugates known in the art by providing a targeted tumor therapy as well as bystander activity to neighboring cells in an important oncology receptor that is only moderately expressed.
