Balderes, Paul J.,Eastman, Scott W.,Erickson, Hans K.,Lugwig, Dale L.,Moxham, Christopher M.,Plowman, Gregory D.,Rigby, Alan C.
申请号：
AU2014366359
公开号：
AU2014366359A1
申请日:
2014.12.11
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The conjugate of the present invention has significant advantages over other conjugates known in the art by providing a targeted tumor therapy as well as bystander activity to neighboring cells in an important oncology receptor that is only moderately expressed.
