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TREATMENT OF MUSCLE WEAR WITH SELECTIVE MODULATORS OF THE ANDROGEN RECEIVER.
专利权人:
GTX; INC.
发明人:
STEINER, MITCHELL,VEVERKA, KAREN,DALTON, JAMES,MILLER, DUANE
申请号:
ES02802565
公开号:
ES2372929T3
申请日:
2002.12.05
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound represented by a structure of formula I: in which G is O or S; X is O; T is OH, OR, -NHCOCH3 or NHCOR Z is NO2, CN, COOH, COR, NHCOR or CONHR; Y is CF3, F, I, Br, Cl, CN, C (R) 3 or Sn (R) 3; Q is alkyl, halogen, CF3, CN, C (R) 3, Sn (R) 3, N (R) 2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR; or Q together with the benzene ring to which it is attached is a condensed ring system represented by structure A, B or C: R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, phenyl, halogen, alkenyl, OH or an aromatic group having at least one carbocyclic aromatic group or a heterocyclic aromatic group; and R1 is CH3, CH2F, CHF2, CF3, CH2CH3 or CF2CF3; or a pharmaceutically acceptable salt, pharmaceutical product, hydrate or N-oxide thereof, for use in the treatment of a muscular wasting disorder caused by muscular dystrophy, muscular atrophy, X-linked spinobulbar muscular atrophy (AMEB), a cachexia , kidney disease or end-stage renal failure.Un compuesto representado por una estructura de fórmula I: en la que G es O o S; X es O; T es OH, OR, -NHCOCH3 o NHCOR Z es NO2, CN, COOH, COR, NHCOR o CONHR; Y es CF3, F, I, Br, Cl, CN, C(R)3 o Sn(R)3; Q es alquilo, halógeno, CF3, CN, C(R)3, Sn(R)3, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R, SR; o Q junto con el anillo de benceno al que se une es un sistema de anillo condensado representado por la estructura A, B o C: R es alquilo, haloalquilo, dihaloalquilo, trihaloalquilo, CH2F, CHF2, CF3, CF2CF3, fenilo, halógeno, alquenilo, OH o un grupo aromático que tiene al menos un grupo aromático carbocíclico o un grupo aromático heterocíclico; y R1 es CH3, CH2F, CHF2, CF3, CH2CH3 o CF2CF3; o una sal farmacéuticamente aceptable, producto farmacéutico, hidrato o N-óxido del mismo, para su uso en el tratamiento de un trastorno de desgast
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