The present invention discloses new polymophys of a NEP inhibitor AHU-377, including polymorphic free acid, hemi-calcium salt and α -phenethylamine salt, as well as preparation method and use thereof. These polymophys improve the physical and chemical properties of AHU-377. The preparation of the invention has the advantage of maturity and strong operability. The product of this method is high quality, uniform and stable, it improves chemical stability, which is conducive to storage and has broad application prospect.本發明公開了一種NEP抑制劑AHU-377新的結晶形式,其中包括結晶型游離酸、半鈣鹽、α-苯乙胺鹽及其製備方法和應用。改善了AHU-377物化性質。發明技術成熟,可操作性強,所得產品品質高且均一穩定,提高了化學穩定性,利於儲存,具有廣闊的應用前景。本案的圖為實驗數據,並非本案的代表圖。故本案無指定代表圖。
