您的位置: 首页 > 农业专利 > 详情页

COMPOSÉ D'HYDRAZIDE TRIFLUOROACÉTIQUE AINSI QUE SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION DANS LA PRÉPARATION D'UN MÉDICAMENT
专利权人:
Guangzhou Magpie Pharmaceuticals Co.; Ltd.
发明人:
WANG, Yuqiang,CHEN, Haiyun,ZHANG, Zaijun,ZHANG, Gaoxiao,YU, Pei,SUN, Yewei,SHAN, Luchen,TAO, Liang
申请号:
EP15874453
公开号:
EP3241824A4
申请日:
2015.08.11
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to trifluoroacetyl hydrazide compounds and methods of preparation and uses thereof. The compounds have a structure of the following formula: The compounds showed multifunctional mechanisms, including inhibition of glutamate excitotoxicity, activation of MEF2 transcriptional activity, clearance of free radicals, and promotion of nerve differentiation, and has a better protective effect on cells especially nerve cells.. The compound can be used to prepare prophylactic or therapeutic medicaments with cytoprotective effects, for the prevention or treatment of diseases related to glutamate receptor activation, MEF2 disorders or excessive free radicals generation. The diseases include neurodegenerative diseases such as Alzheimer's disease, Parkinson and stroke, and the free radicals related diseases such as heart disease, myocardial ischemia, diabetes and other cardiovascular and cerebrovascular diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充