Ralph T. Kubo;Denise Marie Baker;Esteban Celis;John Sidney;Robert Chestnut;Alessandro Sette;Howard M. Grey;Brian D. Livingston;Scott Southwood
发明人:
Alessandro Sette,John Sidney,Scott Southwood,Brian D. Livingston,Robert Chestnut,Denise Marie Baker,Esteban Celis,Ralph T. Kubo,Howard M. Grey
申请号：
US09390061
公开号：
US09266930B1
申请日:
1999.09.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare Plasmodium falciparum epitopes, and to develop epitope-based vaccines directed towards malaria. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of malaria. In particular, this application discloses isolated peptides comprising oligopeptides, for example the oligopeptide GVSENIFLK, or isolated peptides conjugated with T helper peptides that are used as antigens in epitope-based vaccines to prevent and/or treat malaria.
