Plasmodium falciparum LSA-5 liver and blood phase antigens, immunogenic compositions containing this antigen, and vaccines against malaria

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专利权人:

インスティチュート・パスツール

发明人:

ドリュイル， ピエール,ブラヒミ－ゼギドゥール，カリマ,ドリュイル, ピエール,ブラヒミ-ゼギドゥール,カリマ

申请号：

JP2006544395

公开号：

JP4991308B2

申请日:

2004.12.15

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterisation of a novel liver and sporozoite-stage P. falciparum antigen, referred to as LSA-5. This antigen is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90 %). The invention concerns antigenic peptides or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as immunogenic compositions, vaccines and kits comprising these.

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