Hans-Georg Lerchen,Sherif El Sheikh,Beatrix Stelte-Ludwig,Joachim Schuhmacher,Mark Gnoth
申请号：
US14004699
公开号：
US09029406B2
申请日:
2012.03.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and to the use of these derivatives for producing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments may be applied as a monotherapy or else in combination with other medicaments or further therapeutic measures.
