LERCHEN, HANS-GEORG,EL SHEIKH, SHERIF,STELTE-LUDWIG, BEATRIX,SCHUHMACHER, JOACHIM,GNOTH, MARK
申请号：
HK14104335.0
公开号：
HK1191034B
申请日:
2014.05.07
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and to the use of these derivatives for producing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments may be applied as a monotherapy or else in combination with other medicaments or further therapeutic measures.
