Derivatives of pyridazin-3 (2H) -one selective inhibitors of the isoform b of monoamine oxidase (Machine-translation by Google Translate, not legally binding)
UNIVERSIDADE DE VIGO;UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
发明人:
TERAN MOLDES, MARÍA DEL CARMEN,BESADA PEREIRA, PEDRO,COSTAS CAAMANO, TAMARA,COSTAS LAGO, MARÍA DEL CARMEN,VILA MOLARES, NOEMÍ,VINA CASTELAO, DOLORES
申请号：
ES201400162
公开号：
ES2544869A1
申请日:
2014.03.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
This invention relates to pyridazin-3 (2H) -one derivatives of general structure i, ii and iii, which are selective inhibitors of mao-b, and to their use to prepare drugs intended to treat disorders resulting from hyperactivity of the mao-b, in particular degenerative disorders of the central nervous system (cns), such as parkinson's disease (pd), alzheimer's disease (ad) and other dementias. These are pyridazin-3 (2H) -one derivatives which have dithiocarbamate fragments linked to position 4, 5 or 6 via an alkyl chain of variable length (n = 1, 2, 3). This invention is also directed to the preparation of said compounds. (Machine-translation by Google Translate, not legally binding)Esta invención se refiere a derivados de piridazin-3(2H)-ona de estructura general I, II y III, que son inhibidores selectivos de la MAO-B, y a su uso para preparar medicamentos destinados a tratar trastornos derivados de la hiperactividad de la MAO-B, en particular trastornos degenerativos del sistema nervioso central (SNC), como la enfermedad de Parkinson (EP), la enfermedad de Alzheimer (EA) y otras demencias. Se trata de derivados de piridazin-3(2H)-ona que presentan fragmentos de ditiocarbamato enlazados a la posición 4, 5 ó 6 a través de una cadena alquílica de longitud variable (n = 1, 2, 3). Esta invención también se dirige a la preparación de dichos compuestos.
