This invention the vitamin C steering rate type derivative of the allyl propionic acid non steroid characteristic anti- inflammation medicine of eve professional foehn, keto professional foehn and napurokisen etc and that and designs and synthesizes medicinal possible acid or attaching salting of alkali and. The non steroid characteristic anti- inflammation medicine which makes eve professional foehn typical is 1 types of usual solution thermal anesthetic medicine. Other than anti- flame operating, furthermore remarkable pain killing, it possesses the safety which is good to solution thermal action and the emergency, not only the lawful age person, it applies to also taking the old person and the baby and the young child. If that the vitamin C steering rate type derivative and that and it transforms in medicinal possible acid or attaching salting of alkali, be able to improve the water solubility, the vein to be easy to prescribe, effective revelation time to shorten, biological utilization talent improve, the stimulation for the stomach tube to decrease, the ability to pass the blood brain channel to reinforce, as a medicine of new model inflammation suppresion and solution heat, pain killing and arthritis menstruation remedy and stroke characteristic brain obstacle arutsuhaima of the painfully multiple sclerosis cyst characteristic lung tissue symptom premature delivery child artery tube opening existence symptomThe type acknowledgment symptom and it makes prevent and remedies of the cancer/gun of part it is used.本発明はイブプロフェン、ケトプロフェン、ナプロキセンなどのアリルプロピオン酸系非ステロイド性抗炎症薬のビタミンCステアレート系誘導体及びそれと薬用可能な酸またはアルカリとの付加塩を設計及び合成する。イブプロフェンを代表とする非ステロイド性抗炎症薬は常用の解熱鎮痛薬物の1種類である。抗炎作用以外に、さらに顕著な鎮痛、解熱作用及び非常によい安全性を有し、成年者だけでなく、老人及び赤ちゃん、幼児の服用にも適用する。それをビタミンCステアレート系誘導体及びそれと薬用可能な酸またはアルカリとの付加塩に転化すれば、その水溶性を改善でき、静脈投与しやすく、効果発現時間を短縮し、生物学的利用能を向上し、胃腸管に対するその刺激作用を減少し、その血液脳関門を通過する能力を増強し、新型の薬物として消炎、解熱、鎮痛、関節炎・月経痛・多発性硬化症・嚢胞性肺線維症・早産児動脈管開存症の治療、脳卒中・虚血性脳障害・アルツハイマー型認知症及び一部のガンの予防及び治療するに用いられる。
